Phenotype Control of Partially Specified Boolean Networks

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Authors

BENEŠ Nikola BRIM Luboš PASTVA Samuel ŠAFRÁNEK David ŠMIJÁKOVÁ Eva

Year of publication 2023
Type Article in Proceedings
Conference Computational Methods in Systems Biology
MU Faculty or unit

Faculty of Informatics

Citation
Web https://link.springer.com/chapter/10.1007/978-3-031-42697-1_2
Doi http://dx.doi.org/10.1007/978-3-031-42697-1_2
Keywords Boolean networks;Partial specification;Permanent control;Phenotype;Perturbation;Symbolic algorithm
Description Partially specified Boolean networks (PSBNs) represent a promising framework for the qualitative modelling of biological systems in which the logic of interactions is not completely known. Phenotype control aims to stabilise the network in states exhibiting specific traits. In this paper, we define the phenotype control problem in the context of asynchronous PSBNs and propose a novel semi-symbolic algorithm for solving this problem with permanent variable perturbations.
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