Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model

Investor logo
Investor logo
Investor logo
Investor logo

Warning

This publication doesn't include Faculty of Education. It includes Faculty of Medicine. Official publication website can be found on muni.cz.
Authors

HORSKÁ Kateřina SKREDE Silje KUČERA Jan KUZMÍNOVÁ Gabriela SUCHÝ Pavel MICALE Vincenzo RUDÁ Jana

Year of publication 2024
Type Article in Periodical
Magazine / Source CNS NEUROSCIENCE & THERAPEUTICS
MU Faculty or unit

Faculty of Medicine

Citation
Web https://onlinelibrary.wiley.com/doi/10.1111/cns.14565
Doi http://dx.doi.org/10.1111/cns.14565
Keywords adipokine; antipsychotic; lipid profile; methylazoxymethanol; schizophrenia
Attached files
Description Our results demonstrate metabolic vulnerability in female prenatally MAM-exposed rats indicating that findings from healthy animals are likely to provide an underestimated impression of metabolic dysfunction associated with antipsychotics. In the context of metabolic disturbances, neurodevelopmental models possess a relevant background, and the search for adequate animal models should receive more attention within the field of experimental psychopharmacology.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.