Ternary copper(ii) complexes of 1,10-phenanthroline and coumarin-based oxylacetates as pro-apoptotic UPR CHOP inducers

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Authors

MASURI Sebastiano CABIDDU Maria Grazia MORÁŇ Lukáš VESSELÁ Tereza BARTOSIK Martin HAVEL Josef MELONI Francesca CADONI Enzo VAŇHARA Petr PIVETTA Tiziana

Year of publication 2023
Type Article in Periodical
Magazine / Source New Journal of Chemistry
MU Faculty or unit

Faculty of Medicine

Citation
Web https://pubs.rsc.org/en/content/articlelanding/2023/NJ/D3NJ01317K
Doi http://dx.doi.org/10.1039/d3nj01317k
Keywords BIOLOGICAL-ACTIVITY; CYTOTOXIC ACTIVITY; CRYSTAL-STRUCTURE; SDNA-BINDING; CELL-DEATH; CISPLATINPLATINUM; LIGANDS; SYSTEM; ACID
Description We prepared six complexes with the formula [Cu(phen)(2)(Lx)](ClO4)(x: 1-6), where auxiliary ligands Lx are coumarin carboxylate derivatives bearing an oxylacetate moiety in the 6th or 7th position and different substituents in the 3rd or 4th position. Complexes show a pentacoordinated geometry around a metal ion. The possibility to complete the coordination sphere in an octahedral geometry makes the molecule able to further react. Complexes show affinity toward DNA mainly through electrostatic interactions and groove binding, while the interactions with DNA base pairs are guaranteed by the auxiliary ligands. The heteroleptic Cu(ii) complexes show cytotoxic activity in the micromolar concentration range, and mechanistic studies have shown how they can interfere at the endothelial reticulum level inducing the pro-apoptotic branch of the unfolded protein response (UPR). The actin-normalized CHOP to BiP density ratios suggest that the novel compounds induce preferentially the pro-apoptotic UPR signalling driven by the CHOP, in a dose-dependent way and according to the substituents in the coumarin moiety.
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