Biomimetic antimicrobial polymers-Design, characterization, antimicrobial, and novel applications

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Authors

TAKAHASHI Haruko SOVADINOVÁ Iva YASUHARA Kazuma VEMPARALA Satyavani CAPUTO Gregory A. KURODA Kenichi

Year of publication 2023
Type Article in Periodical
Magazine / Source WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
MU Faculty or unit

Faculty of Science

Citation
Web https://wires.onlinelibrary.wiley.com/doi/10.1002/wnan.1866
Doi http://dx.doi.org/10.1002/wnan.1866
Keywords antimicrobial polymers; cancer; cyanobacteria; liposome; simulations
Attached files
Description Biomimetic antimicrobial polymers have been an area of great interest as the need for novel antimicrobial compounds grows due to the development of resistance. These polymers were designed and developed to mimic naturally occurring antimicrobial peptides in both physicochemical composition and mechanism of action. These antimicrobial peptide mimetic polymers have been extensively investigated using chemical, biophysical, microbiological, and computational approaches to gain a deeper understanding of the molecular interactions that drive function. These studies have helped inform SARs, mechanism of action, and general physicochemical factors that influence the activity and properties of antimicrobial polymers. However, there are still lingering questions in this field regarding 3D structural patterning, bioavailability, and applicability to alternative targets. In this review, we present a perspective on the development and characterization of several antimicrobial polymers and discuss novel applications of these molecules emerging in the field. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease
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