Visible-Light-Activated Carbon Monoxide Release from Porphyrin-Flavonol Hybrids

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Authors

RAMUNDO Andrea JANOŠ Jiří MUCHOVÁ Lucie ŠRANKOVÁ Mária DOSTÁL Jakub KLOZ Miroslav VÍTEK Libor SLAVÍČEK Petr KLÁN Petr

Year of publication 2024
Type Article in Periodical
Magazine / Source Journal of the American Chemical Society
MU Faculty or unit

Faculty of Science

Citation
Web https://pubs.acs.org/doi/10.1021/jacs.3c11426
Doi http://dx.doi.org/10.1021/jacs.3c11426
Keywords Flavonoids; Inorganic carbon compounds; Irradiation; Oxides; Pyrroles
Attached files
Description We report on porphyrin-flavonol hybrids consisting of a porphyrin antenna and four covalently bound 3-hydroxyflavone (flavonol) groups, which act as highly efficient photoactivatable carbon monoxide (CO)-releasing molecules (photoCORMs). These bichromophoric systems enable activation of the UV-absorbing flavonol chromophore by visible light up to 650 nm and offer precise spatial and temporal control of CO administration. The physicochemical properties of the porphyrin antenna system can also be tuned by inserting a metal cation. Our computational study revealed that the process occurs via endergonic triplet-triplet energy transfer from porphyrin to flavonol and may become feasible thanks to flavonol energy stabilization upon intramolecular proton transfer. This mechanism was also indirectly supported by steady-state and transient absorption spectroscopy techniques. Additionally, the porphyrin-flavonol hybrids were found to be biologically benign. With four flavonol CO donors attached to a single porphyrin chromophore, high CO release yields, excellent uncaging cross sections, low toxicity, and CO therapeutic properties, these photoCORMs offer exceptional potential for their further development and future biological and medical applications.
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