Potent synergistic effects of dulaglutide and food restriction in prevention of olanzapine-induced metabolic adverse effects in a rodent model

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Authors

HORSKÁ Kateřina KUČERA Jan DRAŽANOVÁ Eva KUZMÍNOVÁ Gabriela AMCHOVÁ Petra HRICKOVÁ Mária RUDÁ Jana SKREDE Silje

Year of publication 2024
Type Article in Periodical
Magazine / Source Biomedicine and Pharmacotherapy
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S0753332224006474
Doi http://dx.doi.org/10.1016/j.biopha.2024.116763
Keywords Antipsychotic; Olanzapine; metabolic adverse effects; GLP-1 receptor agonist; Schizophrenia
Description A combined strategy of dulaglutide and food restriction manifested a massive synergistic benefit. GLP-1RAs represent a promising strategy and deserve thorough future research. Our findings underline the potential importance of lifestyle intervention in addition to GLP-1 RA treatment.
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