Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives

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Authors

JANKOVSKÁ Dagmar JURČOVÁ Nikol KUBÍNOVÁ Renata VÁCLAVÍK Jiří ŠVAJDLENKA Emil MASCELLANI Anna MARSIK Petr BOUZKOVÁ Kateřina MALANÍK Milan

Year of publication 2024
Type Article in Periodical
Magazine / Source PLANTS-BASEL
MU Faculty or unit

Faculty of Pharmacy

Citation
Web https://pubmed.ncbi.nlm.nih.gov/38732396/
Doi http://dx.doi.org/10.3390/plants13091181
Keywords AChE; Amorpha fruticosa; BuChE; molecular docking; putrescine; spermidine
Description Five putrescine and spermidine derivatives (1-5) together with five rotenoids (6-10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 +/- 1.9% for AChE and 90.0 +/- 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.
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