One-Pot Quinazolin-4-yl-thiourea Synthesis via N-(2-Cyano-phenyl)benzimidoyl isothiocyanate

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Authors	MOHAMED Walid Fathalla ČAJAN Michal PAZDERA Pavel MAREK Jaromír
Year of publication	2001
Type	Article in Periodical
Magazine / Source	Molecules
MU Faculty or unit	Faculty of Science
Citation
Field	Organic chemistry
Keywords	1-(2-phenylquinazolin-4-yl)-3-substituted thioureas; quinazolines; thioureas; benzimidoyl isothiocyanates
Description	1-substituted-3-(2-phenylquinazolin-4-yl) thioureas were produced by an intramolecular cycloaddition reaction of 1-substitued-3-[(2-cyanophenylimino)phenyl-methyl]thioureas. These compounds in turn were prepared by a domino reaction of N-(2-cyanophenyl)benzimidoyl isothiocyanate with primary amines. The structures of products were confirmed by FTIR, 1 H-NMR, 13 C-NMR, mass spectroscopy and X-ray crystallography.
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