Matrixmetalloproteinases in the immunopathogenesis of multiple sclerosis

Warning

This publication doesn't include Faculty of Education. It includes Faculty of Medicine. Official publication website can be found on muni.cz.
Authors

BENEŠOVÁ Yvonne NOVOTNÁ Hana BERÁNEK M. ŠTOURAČ Pavel HLADÍKOVÁ Magdaléna

Year of publication 2005
Type Article in Periodical
Magazine / Source Multiple sclerosis
MU Faculty or unit

Faculty of Medicine

Citation
Field Neurology, neurosurgery, neurosciences
Keywords Metalloproteinases; multiple sclerosis; immunopathogenesis
Description Multiple sclerosis (MS) is a chronic autoimmune disorder of the CNS. Matrixmetalloproteinases (MMPs) play a key role in the immunopathogenesis of MS and are significant contributors to the progression of the inflammatory process. There are 23 MMPs known to play a role in the MS disease process. The aim of this study was to analyse the activity of MMP-2 and TIMP-2 in multiple sclerosis and to assess their relationship to the form of the disease. There were 50 patients with definite multiple sclerosis (mean age: 36+/-8 years, mean EDSS score 3.8+/-1.8) studied. Serum levels of MMP-2 and TIMP-2 were quantified by ELISA method in 30 patients with relapsing-remitting form, 10 with definite secondary progressive and 10 with primary progressive form of the disease and compared with those of 50 healthy controls (mean age 36+/-9 years). Mean protein serum levels in control group were: TIMP-2: 47.9 ng/ml, MMP-2: 1887.6 ng/ml. In MS group serum levels were: TIMP-2 46.1 ng/ml, MMP-2 1967.7 ng/ml, in MS group with progressive, and TIMP-2 40.5 ng/ml, MMP-2 2238.5 ng/ml in relapsing-remitting form. There were no statistically significant difference between control and MS groups. The levels of MMP-2 and TIMP-2 were, however, significantly higher in the progressive form of the disease when compared with the relapsing-remitting form of the disease (p< 0.05), probably as a marker of destruction of the nervous tissue.. MMPs ssems to be a promising biological markers which indicate the disease form.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.