The diagnostic significance of intrathecal occurence of selected antiviral antibodies in multiple sclerosis
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Scripta Medica |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | Multiple sclerosis; intrathecal synthesis; MRZ reaction; cerebrospinal fluid |
| Description | Analysis of cerebrospinal fluid (CSF) represents an important role in the diagnosis of multiple sclerosis. Oligoclonal IgG bands ,blood-CSF barrier and cell count are normally examined. Intrathecal synthesis of specific IgG antibodies against measles , rubella and varicella zoster virurses called MRZ reaction is a new diagnostic marker which is present in patients with chronic autoimmune diseases with the involvement of the nervous system , especially multiple sclerosis. The aims of our work were to investigate the frequency of intrathecal synthesis of specific antiviral antibodies and to determine a typical CSF profile in patients with multiple sclerosis.We examined a cohort of 50 patients. The intrathecal synthesis of specific antibodies was evaluated in the form of antibody indices calculated according to Reiberś formula.The condition of blood - CSF barrier was expressed by the ration of albumin in CSF and serum. Oligoclonal IgG bands were detected by isoelectric focusing . Eighty -six percent of multiple sclerosis patients had positive intrathecal synthesis of specific antibodies against one, two or three of the examined neurotropic viruses. 84% of multiple sclerosis patients had positive oligoclonal IgG bands , intact blood-CSF barrier was detected in 70% and pleocytosis in 36% of patients with multiple sclerosis. Highly specific MRZ reaction improves the possibilities of CSF analysis in cases of chronic , inflammatory and autoimmune diseases. The adaptation of MRZ reaction to CSF routine analysis increased considerably the significance of lumbar puncture for the diagnosis of multiple sclerosis, even at the time of first clinical symptoms. |
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