Antioxidant and DNA reparation enzyme genetic polymorphism as a pathogenic factor of diabetic nephropathy

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Authors

PÁCAL Lukáš STEJSKALOVÁ Andrea KAŇKOVÁ Kateřina

Year of publication 2006
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Catalase is an endogenous antioxidant enzyme neutralizing hydrogen peroxide and is induced by oxidative challenge. A -262C/T polymorphism in the promoter region of the gene is a functional variant modulating activity of the enzyme. Ascertained association suggests that variability in the CAT gene may confer a modest genetic risk for the development of diabetic nephropathy in type 2 diabetics in Czech population.
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