Identifikace individuálních autologních kolonů myelom-reaktivních T lymfocytů

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Title in English	Identification of individual autologous clones of myeloma-reaktive T lymphocytes
Authors	DUDOVÁ Silvie HORÁK Radovan KOVÁŘOVÁ Lucie HORVÁTH Radek HÁJEK Roman MICHÁLEK Jaroslav
Year of publication	2006
Type	Article in Periodical
Magazine / Source	Klinická onkologie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Oncology and hematology
Keywords	multiple myeloma ; immunotherapy ; T cell receptor ; hypervariable region ; clonotype
Description	Multiple myeloma (MM) is a hematooncologic disease caused by malignant tranformation of B-lymphocytes, their clonal proliferation and accumulation of terminal stages-plasmocytes (myeloma cells). Recently, high-dose chemotherapy with autologous hematopoietic transplantation has been considered standard treatment for patients with advanced stages of multiple myeloma. Such treatment delays replase but it is not curative and almost all patients ultimately develop recurrent disease.
Related projects:	Rozlišení a molekulární analýza aloreaktivních a nádorově-specifických T lymfocytů in vitro