Glutamatergics and addiction

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Authors	ŠULCOVÁ Alexandra JEŽOVÁ Daniela
Year of publication	2006
Type	Article in Periodical
Magazine / Source	Homeostasis in Health and Diseases
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	addiction; glutamte; memantine; phenytoin; mice;rats
Description	The noncompetitive NMDA receptor antagonist memantine did not produce significant alteration of sensitization either to methamphetamine stimulatory effects on mouse locomotor/exploratory behaviour in the open field test or to methamphetamine inhibitory antiaggressive effects in singly-housed mice on dyadic social interactions with non-aggressive group-housed partners. Blockade of glutamate release by treatment with phenytoin (not changing locomotor behaviour in the open field test) prevented the development of compulsory wheel running - an animal model of excercise addiction in humans.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems