Studium biologických efektů benzo[c]phenanthridinových alkaloidů na nádorových a nenádorových buněčných liniích

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Title in English	The study of biological effects benzo[c]phenanthridine alkaloids on tumour and normal cell lines
Authors	SLUNSKÁ Zdenka SLANINOVÁ Iva
Year of publication	2006
Type	Article in Proceedings
Conference	Sborník 50.studentské vědecké konference LF MU
MU Faculty or unit	Faculty of Medicine
Citation
Field	Genetics and molecular biology
Keywords	benzo[c]phenanthridine alkaloids
Description	Quarternary benzo[c]phenanthridine alkaloids display a wide spectrum of biological effects and they are discussed as a potential cytostatics.We compared effects of major alkaloids sanguinarine and chelerythrine with a minor derivates sanguirubine, chelirubine, sanguilutine, chelilutine and macarpine.Our results showed that IC50 values of tested alkaloids were comparable with IC50 of routinly used cytostatics. Cytotoxicity of individual alkaloids decreased in this order: MA-SL-CHL-SR-CHR-SA-CHE. HeLa and A-2780 were the most sensitive cell lines. All tested alkaloids appeared to be inductors of apoptosis.
Related projects:	Plant sources of benzophenanthridine alkaloids and effects of these alkaloid on normal and cancer cells Molecular and cell biology in biomedicine