Polymorphisms of glutathione S-transferase (GST) M1, T1, and P1 in patients with reflux esophagitis and Barretts esophagus

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Authors	KALA Zdeněk DOLINA Jiří MAREK Filip IZAKOVIČOVÁ HOLLÁ Lydie
Year of publication	2007
Type	Article in Periodical
Magazine / Source	J Hum Genet
MU Faculty or unit	Faculty of Medicine
Citation
Field	Surgery incl. transplantology
Keywords	GERD; GSTs; glutathione S-transferase; polymorphism; reflux esophagitis; gene; Barretts esophagus
Description	Reflux esophagitis (RE) and Barretts esophagus belong to the most common esophageal complications of gastroesophageal reflux disease. Glutathione S-transferase (GST) enzymes play an important role in cellular protection against oxidative stress and toxic foreign chemicals. Therefore, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes could influence susceptibility to RE and Barretts esophagus.
Related projects:	Genetické determinanty pro-/antioxidační rovnováhy v patogeneze respiračních nemocí Zefektivnění diagnostiky a léčby gastroezofageální refluxní choroby jícnu