Polymorphisms of glutathione S-transferase (GST) M1, T1, and P1 in patients with reflux esophagitis and Barretts esophagus

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Authors

KALA Zdeněk DOLINA Jiří MAREK Filip IZAKOVIČOVÁ HOLLÁ Lydie

Year of publication 2007
Type Article in Periodical
Magazine / Source J Hum Genet
MU Faculty or unit

Faculty of Medicine

Citation
Field Surgery incl. transplantology
Keywords GERD; GSTs; glutathione S-transferase; polymorphism; reflux esophagitis; gene; Barretts esophagus
Description Reflux esophagitis (RE) and Barretts esophagus belong to the most common esophageal complications of gastroesophageal reflux disease. Glutathione S-transferase (GST) enzymes play an important role in cellular protection against oxidative stress and toxic foreign chemicals. Therefore, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes could influence susceptibility to RE and Barretts esophagus.
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