Synthesis of New 1-Substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene) Thiosemicarbazide

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Authors

FATHALA Mohamed Walid PAZDERA Pavel

Year of publication 2007
Type Article in Proceedings
Conference 11th INTERNATIONAL ELECTRONIC CONFERENCE ON SYNTHETIC ORGANIC CHEMISTRY
MU Faculty or unit

Faculty of Science

Citation
Web http://www.usc.es/congresos/ecsoc/11/ECSOC11.htm
Field Organic chemistry
Keywords quinazoline; thiosemicarbazide; domino reaction; hydrogen bond interaction
Description Two new 1-substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene) thiosemicarbazides 3 and 5 were formed by multistep domino reaction of imidoyl isothiocyanate derivative 1 with 1,1-di-R hydrazine in acetone solution. Applied hydrazine hydrate under the same reaction condition afforded 4-(2-phenylquinazolin-4(3H)-ylidene)-2-(prop-1-en-2-yl)-1- (propan-2-lidene) thiosemicarbazide (7) via six step three component domino reaction. Compounds 3, 5 and 7 were identified by CHNS elemental analysis, 1H-NMR, 13C-NMR spectral data and their correlation with ones from known structural motives.
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