Synthesis of New 1-Substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene) Thiosemicarbazide

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Authors	FATHALA Mohamed Walid PAZDERA Pavel
Year of publication	2007
Type	Article in Proceedings
Conference	11th INTERNATIONAL ELECTRONIC CONFERENCE ON SYNTHETIC ORGANIC CHEMISTRY
MU Faculty or unit	Faculty of Science
Citation
Web	http://www.usc.es/congresos/ecsoc/11/ECSOC11.htm
Field	Organic chemistry
Keywords	quinazoline; thiosemicarbazide; domino reaction; hydrogen bond interaction
Description	Two new 1-substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene) thiosemicarbazides 3 and 5 were formed by multistep domino reaction of imidoyl isothiocyanate derivative 1 with 1,1-di-R hydrazine in acetone solution. Applied hydrazine hydrate under the same reaction condition afforded 4-(2-phenylquinazolin-4(3H)-ylidene)-2-(prop-1-en-2-yl)-1- (propan-2-lidene) thiosemicarbazide (7) via six step three component domino reaction. Compounds 3, 5 and 7 were identified by CHNS elemental analysis, 1H-NMR, 13C-NMR spectral data and their correlation with ones from known structural motives.
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