Brain metabolism and diffusion in the rat cerebral cortex during pilocarpine-induced status epilepticus

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Authors

ŠLAIS Karel VOŘÍŠEK Ivan ZOREMBA Norbert HOMOLA Aleš DMYTRENKO Lesia SYKOVÁ Eva

Year of publication 2008
Type Article in Periodical
Magazine / Source Experimental Neurology
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords Diffusion; ADCW; Microdialysis; Pilocarpine; Epilepsy; Glucose; Glutamate; Pyruvate; Lactate; Potassium
Description The real-time iontophoretic method using tetramethylammonium-selective microelectrodes and diffusion-weighted magnetic resonance imaging were used to measure the extracellular space volume fraction, tortuosity and apparent diffusion coefficient of water (ADCW) 240 min after the administration of pilocarpine in urethane-anaesthetized rats. The obtained data were correlated with extracellular lactate, glucose, and glutamate concentrations and the lactate/pyruvate-ratio, determined by intracerebral microdialysis.
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