Haplotype analysis of the endothelial nitric oxide synthase (eNOS) gene in asthma

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Authors	IZAKOVIČOVÁ HOLLÁ Lydie JURAJDA Michal POHUNEK Petr ZNOJIL Vladimír
Year of publication	2008
Type	Article in Periodical
Magazine / Source	Hum Immunol
MU Faculty or unit	Faculty of Medicine
Citation
Field	Epidemiology, infectious diseases and clinical immunology
Keywords	asthma; gene; nitric oxide synthase; NOS3; polymorphisms
Description	Nitric oxide (NO) is an important mediator of physiologic processes in the airways. There is evidence that genetic factors affect NO formation and contribute to the pathophysiology of asthma. The aims of this study were to determine the eNOS haplotypes in Czech asthmatics and control subjects and to examine their relation to asthma. Our findings suggest that endothelial NOS variants may be one of the factors participating in protection or susceptibility to asthma in our population.
Related projects:	Genetické determinanty pro-/antioxidační rovnováhy v patogeneze respiračních nemocí