Chromocentre integrity and epigenetic marks

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Authors

HARNIČAROVÁ Andrea GALIOVÁ Gabriela LEGARTOVÁ Soňa KOZUBEK Stanislav MATULA Pavel BÁRTOVÁ Eva

Year of publication 2010
Type Article in Periodical
Magazine / Source Journal of Structural Biology
MU Faculty or unit

Faculty of Informatics

Citation
Doi http://dx.doi.org/10.1016/j.jsb.2009.09.007
Field Genetics and molecular biology
Keywords SUV39h; epigenetics; histone methylation
Description The epigenetic modification of histones dictates the formation of euchromatin and heterochromatin domains. We studied the effects of a deficiency of histone methyltransferase, SUV39h, and trichostatin A-dependent hyperacetylation on the structural stability of centromeric clusters, called chromocentres. We did not observe the expected disintegration of chromocentres, but both SUV39h deficiency and hyperacetylation in SUV39h+/+ cells induced the re-positioning of chromocentres closer to the nuclear periphery.
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