Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: An expression profiling study.
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Experimental and Clinical Cancer Research |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | neuroblastoma; expression profiling; retinoids; ATRA; caffeic acid; celecoxib |
| Description | Expression profiling of 440 cancer-related genes in two neuroblastoma cell lines, SK-N-BE(2) a SH-SY5Y, after combined treatment with all-trans retinoic acid (ATRA) and LOX/COX inhibitors was performed. Cluster analyses of the changes in gene expression showed the concentration-dependent increase in genes known to be involved in the process of retinoid-induced neuronal differentiation, especially in cytoskeleton remodeling. These changes were detected in both cell lines, and they were independent of the type of specific inhibitors, suggesting a common mechanism of ATRA-induced differentiation enhancement. |
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