SPECTROSCOPIC STUDY OF PROTONATION EQULIBRIA OF SHORT OLIGONUCLEOTIDES CONTAINING CYTOSIN

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Authors

HOLUBOVÁ Sylvie LUBAL Přemysl TRNKOVÁ Libuše

Year of publication 2010
Type Article in Proceedings
Conference X. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků
MU Faculty or unit

Faculty of Science

Citation
Field Analytic chemistry
Keywords oligonucleotides; cytosine; equilibria; spectroscopy
Description This paper deals with the spectroscopic study of protonation of short deoxyoligonucleotides (ODNs) containing cytosine. The measurements were performed at constant temperature and ionic strength. The influence of the number of cytosine in the ODNs chain on protonation was studied. The pKa values were calculated using the software OPIUM. Constants pKa determined at several temperatures provided the possibility to calculate the thermodynamic parameters such as enthalpy and entropy.
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