c-Myb promotes invasivity of breast cancer cells

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Authors

KNOPFOVÁ Lucia TRČKA Filip BENEŠ Petr ŠMARDA Jan

Year of publication 2010
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description The aim of this study was to assess the role of the c-Myb protein in control of invasivity of breast cancer cells. MDA-MB-231 breast cancer cells were transfected with the c-Myb coding cDNA to prepare MDA-MB-231MYBup derivatives. MDA-MB-231MYBup cells were significantly more active in both motility and invasion than controls as determined by Cultrex cell invasion assay. This was clearly confirmed by real-time analysis of cell migration/invasion. To address the mechanism of c-Myb-enhanced breast cancer cell invasion, we examined the role of c-Myb in control of expression and activity of some of the proteases involved in degradation of extracellular matrix. We found that c-Myb enhanced production of cathepsin D and matrix metaloproteinases in MDA-MB-231MYBup cells. These results suggest a novel role of c-Myb protein in control of tumor invasion and metastatic progression.
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