c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo
| Authors | |
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| Year of publication | 2011 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Metastasis formation and spread of primary tumors are the leading causes of death in cancer patients. To develop new treatment strategies, a clarification of the processes involved in the metastasis development is required. The c-Myb transcription factor is essential regulator of stem-progenitor cells in bone marrow, colon epithelia and neurogenic niches in brain. Malfunction of c-Myb results in malignancies of several types. The role of c-Myb in regulation of proliferation, differentiation and apoptosis is well established. In contrast, current knowledge on the role of c-Myb in control of metastasis formation remains poor. We have reported recently, that c-Myb promotes migration/invasion of human breast cancer MDA-MB-231 cells via upregulation of cathepsin D and MMP9. This study shows that overexpression of c-myb enhances migration and invasion of murine breast cancer 4T1 cells and murine colon cancer CT26 cells in vitro as well. |
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