Clinical importance of matrix metalloproteinases

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Authors

KŘÍŽKOVÁ S. ZÍTKA O. MASAŘÍK Michal ADAM V. STIBOROVÁ M. ECKSCHLAGER T. HUBÁLEK J. KIZEK R.

Year of publication 2011
Type Article in Periodical
Magazine / Source Bratislavské lékařské listy
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords matrix metalloproteinases; clinical diagnostics; zymography; cancer
Description This review gives a brief summary on clinical applications of MMPs and their determination. Primarily, the activity of MMPs in cancer formation, development and metastasis is discussed. Further, survey on methods including fluorimetric methods, zymographies, Western-blotting, immunocapture assay, enzyme-linked immunosorbent assay, immunocytochemistry and immunohistochennistry, phage display, multiple-enzyme/multiple-reagent system, activity profiling, chronopotentiometric stripping analysis and imaging methods for detection and determination of MMPs follows (Fig. 3, Ref. 100).
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