Bilateral propagation of neuroinflammatory reaction in dorsal root ganglia alongside the neuroaxis in a neuropathic pain model
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| Year of publication | 2011 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Background and aims: Compelling evidence indicates that neuropathic pain induced by nerve injury is related to neuroinflammation in the dorsal root ganglia (DRG) containing the primary afferent neurons. The aim of our work was to test whether neuroinflammatory reaction can spread to DRG nonassociated with injured nerve. Results: Although mechanoallodynia and thermal hyperalgesia were detected in the ipsilateral hind paws from 1 to 14 days, only temporal behavioral changes were measured in contralateral hind paws and in fore paws of both sides. However, cytokine proteins and their synthesis were enhanced bilaterally in both cervical and lumbar DRG following CCI. A moderate increase of cytokine proteins and synthesis was also found in DRG from sham-operated animals. Conclusions: Cytokine proteins and their synthesis in DRG per se are not completely correlated with neuropathic pain induction. Cytokine changes in DRG could rather be related to a general neuroinflammatory reaction of the nervous system to injury. |
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