Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice

Investor logo

Warning

This publication doesn't include Faculty of Education. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.
Authors

MÁCHALOVÁ Alena ŠLAIS Karel VRSKOVA Dagmar ŠULCOVÁ Alexandra

Year of publication 2012
Type Article in Periodical
Magazine / Source Pharmacology Biochemistry and Behavior
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.sciencedirect.com/science/article/pii/S0091305712001232
Doi http://dx.doi.org/10.1016/j.pbb.2012.04.013
Field Neurology, neurosurgery, neurosciences
Keywords Psychostimulant; Modafinill; Methamphetamine; MDMA; Agnostic behavior; Mice
Description The aim of the present study was to compare the behavioral effects of modafinil, an atypical psychostimulatory acting and cognitive-function improving drug, with the effects of the psychostimulants methamphetamine (MET) and MDMA (3,4-methylenedioxymethamphetamine, or “ecstasy”) in a model of mouse agonistic behavior. This model enables the observation of ethologically well-defined sociable, timid, aggressive, and locomotor behavioral acts and postures. Singly-housed male mice (isolates)were separated into 4 groups. The observations were performed in 4 sessions, 1 week apart. In each interaction, singly-housed mice were paired with nonaggressive group-housed partners for 4 min in a neutral environment. The isolates received, in a Latin square design, either a) a vehicle or modafinil at doses 2.0, 10.0, or 50.0 mg/kg; or b) a vehicle or MET at doses 1.0, 5.0, or 10.0 mg/kg; or c) a vehicle or MDMA at doses 2.5, 10.0, or 30.0 mg/kg. The isolates were categorized as timid or aggressive according to their behavior in the control interaction (vehicle pre-treatment). Elements of locomotor, sociable, aggressive, and timid behavior were evaluated (one-way ANOVA).
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.