The role of voxel-based morphometry in the detection of cortical dysplasia within the temporal pole in patients with intractable mesial temporal lobe epilepsy

• Authors: PAIL Martin; MAREČEK Radek; HERMANOVÁ Markéta; SLANÁ Bronislava; TYRLÍKOVÁ Ivana; KUBA Robert; BRÁZDIL Milan
• Year of publication: 2012
• Type: Article in Periodical
• Magazine / Source: Epilepsia
• MU Faculty or unit: Central European Institute of Technology
• web: http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2012.03456.x/abstract
• Doi: http://dx.doi.org/10.1111/j.1528-1167.2012.03456.x
• Field: Neurology, neurosurgery, neurosciences
• Keywords: Hippocampal sclerosis; Malformations of cortical development; Focal cortical dysplasias; Mesial temporal lobe epilepsy; Voxel-based morphometry; Temporal pole
• Description: Purpose: To determine whether voxel-based morphometry (VBM) might contribute to the detection of cortical dysplasia within the temporal pole in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE/ HS). Key Findings: Histopathologic examination revealed cortical dysplasia within the temporal pole in 11 patients. Significance: We found that VBM made a superior contribution to the detection of temporopolar structural malformations (cortical dysplasia) compared to visual inspection. The agreement with postoperative histopathologic proof was clearly significant for VBM results and nonsignificant for visual inspection.

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