Elevace plazmatických hladin BAFF (B-cell activating factor) u pediatrických pacientů s akutní lymfoblastickou leukémií oproti B-lymfomům
| Title in English | Elevation of B-cell activating factor (BAFF) levels in paediatric patients with acute lymphoblastic leukemia compared to other B-lineage malignancies |
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| Authors | |
| Year of publication | 2012 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | There is emerging evidence that B-lineage neoplasms have aberrant expression of B-cell activating factor (BAFF) that enables the B cells to escape apoptosis. The aim of the study therefore was to investigate circulating levels of BAFF in paediatric malignancies related to B-cell growth, i.e. B-cell acute lymphoblastic leukaemia (B-ALL) and B-lineage lymphomas. We observed significant differences in circulating levels of BAFF between the B-ALL patients and B-cell lymphoma patients, the circulating levels of BAFF being substantially higher in B-ALL cases. |
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