Comment on "Computational Model for Predicting Experimental RNA and DNA Nearest-Neighbor Free Energy Rankings"
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Physical Chemistry B |
| MU Faculty or unit | |
| Citation | |
| Web | http://pubs.acs.org/doi/abs/10.1021/jp300659f?mi=0&af=R&pr... |
| Doi | http://dx.doi.org/10.1021/jp300659f |
| Field | Biophysics |
| Keywords | ACID BASE-PAIRS; STACKING ENERGIES; STABILITY; PARAMETERS; STEPS |
| Attached files | |
| Description | Recently, Johnson et al.1 reported interesting quantumchemical computations on base stacking and base pairing energies in B-DNA and A-RNA. They deduced that “there most definitely is a quantitative correlation between the quantum mechanical gas-phase stacking data and nucleic acid stability”. Such conclusion is, in our opinion, too optimistic and oversimplified. We identified several issues questioning the validity of this statement. |
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