MOLEonline 2.0: Interactive Web-based Analysis of Biomacromolecular Channels
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Nucleic Acids Research |
| MU Faculty or unit | |
| Citation | |
| web | http://nar.oxfordjournals.org/content/40/W1/W222.full |
| Doi | http://dx.doi.org/10.1093/nar/gks363 |
| Field | Physical chemistry and theoretical chemistry |
| Keywords | CYTOCHROMES P450; PROTEIN STRUCTURES; NUCLEIC-ACIDS; SUBSTRATE PREFERENCES; POTASSIUM CHANNEL; PHOTOSYSTEM-II; ACTIVE-SITES; IDENTIFICATION; TUNNELS; MACROMOLECULES |
| Description | Biomolecular channels play important roles in many biological systems, e.g. enzymes, ribosomes and ion channels. This article introduces a web-based interactive MOLEonline 2.0 application for the analysis of access/egress paths to interior molecular voids. MOLEonline 2.0 enables platform-independent, easy-to-use and interactive analyses of (bio)macromolecular channels, tunnels and pores. Results are presented in a clear manner, making their interpretation easy. For each channel, MOLEonline displays a 3D graphical representation of the channel, its profile accompanied by a list of lining residues and also its basic physicochemical properties. The users can tune advanced parameters when performing a channel search to direct the search according to their needs. The MOLEonline 2.0 application is freely available via the Internet at http://ncbr.muni.cz/mole or http://mole.upol.cz. |
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