| Description |
Aim of the study: Anthracyclines are chemotherapeutics most used in treatment of different tumors. Treatment has several side effects as cardiotoxicity and longtime regulation changes of blood pressure. Arterial stiffness is considered as sign of structural changes of arterial wall and it is crucial in pathogenesis of cardiovascular diseases. Analysis of pulse wave and pulse wave velocity (PWV) are some of noninvasive methods of arterial stiffness determination. These parameters indices risk of cardiovascular disease development in adolescents. Aim of the study is to evaluate differences in basic parameters of arterial stiffness assessment between group of oncological patients treated by anthracyclines and group of healthy controls. Subjects and Methods: We examined 15 patients after anthracycline therapy (group P, age 17,2+-1,6 years, 8,5+-2,6 years after end of therapy, dose of anthracyclin 226,4+-28,1 mg/m2,, the most frequent diagnosis: acute lymphoblastic leukemia) and 50 healthy controls (group C, age: 17,3+-0,9 years). We measured augmentation pressure (AP), augmentation index standardized on hear rate 75/min (AIx75), Buckberg index (SEVR) and PWV. These parameter were measured by aplanation tonometry (Sfygmocor, AtCor Medical, Australia). Statistics: Man-Whitney unpaired test. Results: We found significant increase of Alx (P versus C: -1,48+-5,91 vs. -4,45+-7,73 %, p<0,05). Other parameters didn’t vary significantly (AP: 0,17+-2,05 vs. -0,37+-2,33 mmHg, p=ns; SEVR:174,2+-25,5 vs. 176,4+-37,2%, p=ns; PWV: 6,61+-0,88 vs. 6,65+-0,92 m/s, p=ns). Conclusion: We showed that adolescents cured by antracyclines in childhood have increased augmentation index as one of parameters determined arterial stiffness. Supported by specific research MUNI/A/0846/2011.
|