Protein enginnering of mannosidase

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Authors	DEMO Gabriel HORSKÁ Veronika FRIEDLOVA Barbora WEIGNEROVA Lenka WIMMEROVÁ Michaela
Year of publication	2012
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	N-Acetyl-D-mannosamine (ManNAc) is often used as a precursor in the chemical or enzymatic synthesis of the neuraminic acids found in glycolipids and glycoproteins. ManNAc is also a synthetic intermediate for a number of carbohydrate-derived families of biologically active compounds and pharmaceutical candidates. The main goal of this work is to produce N-acetyl-mannosaminidase via mutagenesis of mannosidase and to employ it in enzymatic synthesis of compounds containing ManNAc.
Related projects:	Enzymy metabolismu mannosidů v přípravě N-acetyl-mannosaminových struktur