Project information
Aberrant Splicing of CFTR Exon 9 (ASCE)

Information

This project doesn't include Faculty of Education. It includes Central European Institute of Technology. Official project website can be found on muni.cz.
Investor logo
Project Identification
630758
Project Period
3/2014 - 2/2018
Investor / Pogramme / Project type
European Union
MU Faculty or unit
Central European Institute of Technology

Alternative splicing of pre-mRNAs is tightly regulated and any imbalance can change the outcome of gene expression which often leads to disease. Despite the importance of alternative splicing regulation our knowledge at the molecular level is still in its infancy hampering development of effective therapies. We plan to study the regulatory RNA-protein and proteinprotein interaction networks leading to skipping of CFTR exon 9 associated with severe forms of cystic fibrosis. Structure
determination of regulatory complexes by NMR spectroscopy in combination with biochemical and functional in vivo studies will be used to deepen our molecular understanding of the regulatory networks governing the proper assembly of mRNAs.
With this, we want to reveal the molecular basis of aberrant CFTR exon 9 splicing and lay a rational, structure-functionbased
foundation for novel approaches to cure diseases.

Publications

Total number of publications: 3


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