Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2015043
- Project Period
- 1/2016 - 12/2019
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publications
Total number of publications: 313
2019
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Experimental Investigation of Thermal Properties of Binary Metal Alloys
Year: 2019, type: Appeared in Conference without Proceedings
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Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase
Proceedings of the National Academy of Sciences of the United States of America, year: 2019, volume: 116, edition: 10, DOI
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Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters
CHEM, year: 2019, volume: 5, edition: 2, DOI
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Fucosylated inhibitors of recently identified bangle lectin from Photorhabdus asymbiotica
Scientific reports, year: 2019, volume: 9, edition: 1, DOI
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Globální analýza NF-κB proteinových komplexů v modelu luminálních A nádorů prsu pomocí SEC-LC-MS/MS
Year: 2019, type: Conference abstract
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Human Stress-inducible Hsp70 Has a High Propensity to Form ATP-dependent Antiparallel Dimers That Are Differentially Regulated by Cochaperone Binding
MOLECULAR & CELLULAR PROTEOMICS, year: 2019, volume: 18, edition: 2, DOI
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Human Telomere Repeat Binding Factor TRF1 Replaces TRF2 Bound to Shelterin Core Hub TIN2 when TPP1 Is Absent
Journal of Molecular Biology, year: 2019, volume: 431, edition: 17, DOI
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Hymenobacter humicola sp. nov., isolated from soils in Antarctica
International Journal of Systematic and Evolutionary Microbiology, year: 2019, volume: 69, edition: 9, DOI
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Hypervalent Iodine Based Reversible Covalent Bond in Rotaxane Synthesis
Angewandte Chemie International Edition, year: 2019, volume: 58, edition: 50, DOI
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Characterization of nanoparticles and proteins by AFM
Year: 2019, type: Workshop