Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Cooperating Organization
-
Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 180
2022
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Reduced graphene oxide/ZnO nanocomposite modified electrode for the detection of tetracycline
Journal of materials science, year: 2022, volume: 57, edition: 9, DOI
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Seeing the invisible – Study of transiently formed protein conformation found in domain 1.1 of bacterial transcription factor
Year: 2022, type: Appeared in Conference without Proceedings
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Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy
Angewandte Chemie International Edition, year: 2022, volume: 61, edition: 48, DOI
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Short Synthesis of (+)-Actinobolin: Simple Entry to Complex Small-Molecule Inhibitors of Protein Synthesis
Angewandte Chemie International Edition, year: 2022, volume: 61, edition: 17, DOI
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Single Molecules Imaging under SemiPhysiological conditions
Year: 2022, type: Workshop
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Structural analysis of pyrene-labelled G-quadruplexes derived from the KIT proto-oncogene
Year: 2022, type: Conference abstract
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Synthesis of Glycoluril Dimers with the Ability to Form Polymeric Self-Associates in Water
Chemistry, year: 2022, volume: 4, edition: 3, DOI
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Technologies for drug discovery at CEITEC Biomolecular Interactions and Crystallization CF
Year: 2022, type:
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The role of bivalent ions in the regulation of D-loop extension mediated by DMC1 during meiotic recombination
iSCIENCE, year: 2022, volume: 25, edition: 11, DOI
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To homodimerize or to heterodimerize: story of 14-3-3 protein dimer formation
Year: 2022, type: Conference abstract