Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Cooperating Organization
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Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 328
2023
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Utility of RNA sequencing for transcriptome analysis of small extracellular vesicles derived from blood sera of colorectal cancer patients
Year: 2023, type: Conference abstract
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Vaccination against tick-borne encephalitis elicits a detectable NS1 IgG antibody response
Journal of Virological Methods, year: 2023, volume: 322, edition: December, DOI
2022
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14-3-3 protein isoforms: mutual dimerization propensities screening kit
Year: 2022, type: Conference abstract
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35th NMR Valtice
Year: 2022, type: Conference
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A GP1BA Variant in a Czech Family with Monoallelic Bernard-Soulier Syndrome
International Journal of Molecular Sciences, year: 2022, volume: 23, edition: 2, DOI
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A large-scale assay library for targeted protein quantification in renal cell carcinoma tissues
Proteomics, year: 2022, volume: 22, edition: 7, DOI
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A new fibrillization mechanism of β-lactoglobulin in glycine solutions
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, year: 2022, volume: 216, edition: SEP, DOI
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A release of Ti-ions from nanostructured titanium oxide surfaces
Surfaces and Interfaces, year: 2022, volume: 29, edition: April 2022, DOI
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A switch from alpha-helical to beta-strand conformation during co-translational protein folding
EMBO Journal, year: 2022, volume: 41, edition: 4, DOI
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Adamantane-Substituted Purine Nucleosides: Synthesis, Host-Guest Complexes with beta-Cyclodextrin and Biological Activity
International Journal of Molecular Sciences, year: 2022, volume: 23, edition: 23, DOI