Project information
Exploring clonal evolution and causes of modern targeted therapy failure in CLL
- Project Identification
- MUNI/IGA/1640/2020
- Project Period
- 1/2021 - 12/2021
- Investor / Pogramme / Project type
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Masaryk University
- Internal grant agency MU
- MU Faculty or unit
- Faculty of Medicine
The aim of the project is to study a mutation profile in patients with chronic lymphocytic leukemia (CLL) - a diagnosis with highly heterogenous genetic background and overal survival of patients. We plan to explore somatic mutations expanding after a specific type of therapy and correlate such mutations with consequent disease evolution. This could help with tailoring further therapy lines in order to eliminate the risk of development of therapy resistance.
Publications
Total number of publications: 7
2021
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Detailed analysis of treatment-related clonal evolution in CLL through the identification of abnormal molecular pathways.
Year: 2021, type: Conference abstract
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Duplikace 8q24 v chronické lymfocytární leukémii: Cytogentická a molekulárně-biologická analýza aberací genu MYC.
Year: 2021, type: Conference abstract
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Exploring clonal evolution and causes of therapy failure in chronic lymphocytic leukemia.
Year: 2021, type: Conference abstract
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Exploring clonal evolution and genetic causes of therapy failure in chronic lymphocytic leukemia.
Year: 2021, type: Conference abstract
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Chromothripsis in Chronic Lymphocytic Leukemia: A Driving Force of Genome Instability
Frontiers in Oncology, year: 2021, volume: 11, edition: November 2021, DOI
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Klonální evoluce CLL – význam BCR receptoru a abnormalit genu TP53.
Year: 2021, type: Conference abstract
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Klonální evoluce CLL podmíněná léčbou: analýza pomocí celoexomového sekvenování.
Year: 2021, type: Conference abstract