Project information
CIISB - Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2023042
- Project Period
- 1/2023 - 12/2026
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Project Website
- https://www.ciisb.org/
- Cooperating Organization
-
Institute of Biotechnology CAS
- Responsible person Ing. Jan Dohnálek, PhD.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed national infrastructure, which consists of two nodes, one represented by CEITEC (Central European Institute of Technology, Brno) and second by BIOCEV (Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University, Vestec near Prague). CIISB offers access to 10 core facilities; five of them are part of the Centre of Structural Biology and one of the Mendel Centre of Genomics and Proteomics of Plants of CEITEC Masaryk University and four of the Centre of Molecular Structure of the Institute of Biotechnology AS CR in the BIOCEV Centre.
All CIISB core facilities are in the full operational phase. Projects as OP RDI (Start-up) supported the construction phase, and the built capacities were made available by both CIISB nodes in the form of Open Access to internal and external users. In its construction phase, CIISB (2011-2015) was the Associated National Center of the pan-European research infrastructure INSTRUCT. In 2016, following the completion, putting into operation, and subsequent international evaluation, CIISB became a fully-fledged Instruct-CZ Centre for this distributed infrastructure.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 125
2024
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Enantioselective Transfer Hydrogenation of α-Methoxyimino-β-keto Esters
Journal of Organic Chemistry, year: 2024, volume: 89, edition: 18, DOI
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Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant
CLINICAL EPIGENETICS, year: 2024, volume: 16, edition: 1, DOI
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Fibrotic extracellular matrix impacts cardiomyocyte phenotype and function in an iPSC-derived isogenic model of cardiac fibrosis
Translational Research, year: 2024, volume: 273, edition: November 2024, DOI
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Final iNEXT-Discovery Consortium Meeting & 4th Symposium on Recent Advances in Cryo-EM
Year: 2024, type: Workshop
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Global interactome mapping reveals pro-tumorigenic interactions of NF-κB in breast cancer
Molecular and Cellular Proteomics, year: 2024, volume: 23, edition: 4, DOI
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Growth Phase Matters: Boosting immunity via Lacticasebacillus-derived membrane vesicles and their interactions with TLR2 pathways
Journal of Extracellular Biology, year: 2024, edition: 3, DOI
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Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3zeta protein variants
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, year: 2024, volume: 266, edition: Pt 2, DOI
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How does phosphorylation affect interaction between 14-3-3ζ and Tau proteins?
Year: 2024, type: Conference abstract
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Hyaluronic Acid Nanoparticles with Parameters Required for In Vivo Applications: From Synthesis to Parametrization
Biomacromolecules, year: 2024, volume: 25, edition: 8, DOI
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Hyaluronic acid-based hydrogels with tunable mechanics improved structural and contractile properties of cells
Biomaterials Advances, year: 2024, volume: 159, edition: May 2024, DOI