Project information
How the study spatial order of specific genetic loci in nuclei of healthy and malignant tissues can contribute to the diagnostics and treatment of solid tumors.

Information

This project doesn't include Faculty of Education. It includes Faculty of Medicine. Official project website can be found on muni.cz.

Project Identification

NC5955

Project Period

1/2000 - 1/2002

Investor / Pogramme / Project type

Ministry of Health of the CR

R&D of Oncology

MU Faculty or unit

Faculty of Medicine

Other MU Faculty/Unit

Faculty of Informatics

prof. RNDr. Michal Kozubek, Ph.D.

Cooperating Organization

Institute of Biophysics

Responsible person Ing. Emilie Lukášová, CSc.

St. Anne's University Hospital Brno

Responsible person MUDr. Karel Hušek, CSc.

Masaryk Memorial Cancer Institute Brno

Responsible person MUDr. Václav Vagunda, Ph.D.

Location of principal genes involved in the development of colorectal carcinoma in cell nuclei of individuals with increased risk of cancer induction will be analyzed by means of confocal fluorescence microscopy in real time.

Publications

Total number of publications: 9

2003

Arrangement of chromosome 11 and 22 territories, EWSR1 and FLI-1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells

TASLEROVÁ Renata KOZUBEK Stanislav LUKÁŠOVÁ Emilie JIRSOVÁ Pavla BÁRTOVÁ Eva KOZUBEK Michal

Article in Periodical

Human Genetics, year: 2003, volume: 112, edition: 2

2002

3D Structure of the human genome: Order in randomness

KOZUBEK Stanislav LUKÁŠOVÁ Emilie JIRSOVÁ Pavla KOUTNÁ Irena KOZUBEK Michal GAŇOVÁ Alena BÁRTOVÁ Eva FALK Martin TASLEROVÁ Renata

Article in Periodical

Chromosoma, year: 2002, volume: 111, edition: 5
Optimisation of FISH Methodology for the Study of 3D Structure of Cell Nuclei Using Micro Axial Tomography

SKALNÍKOVÁ Magdalena KOZUBEK Michal MATULA Petr BÁRTOVÁ Eva EIPEL Heinz HAUSMANN Michael

Article in Proceedings

Biophysics of the Genome and Its Interactions, year: 2002
Spatial distribution of centromeric and subtelomeric DNA sequences in interphase nuclei of human Go and stimulated lymphocytes

AMRICHOVÁ Jana LUKÁŠOVÁ Emilie KOZUBEK Stanislav JIRSOVÁ Pavla KOZUBEK Michal

Article in Proceedings

Biophysics of the genome and its interactions, year: 2002
Structure of the human genome: Experimental results and models

KOZUBEK Stanislav LUKÁŠOVÁ Emilie BÁRTOVÁ Eva KOUTNÁ Irena JIRSOVÁ Pavla KOZUBEK Michal GAŇOVÁ Alena PASEKOVÁ Renata AMRICHOVÁ Jana FALK Martin HLOŽEK Pavel

Article in Proceedings

Biophysics of the genome and its interactions, year: 2002
The 3D structure of human chromosomes in cell nuclei

LUKÁŠOVÁ Emilie KOZUBEK Stanislav KOZUBEK Michal FALK Martin AMRICHOVÁ Jana

Article in Periodical

Chromosome Research, year: 2002, volume: 10, edition: 7
Topography of genetic elements of X-chromosome relative to the cell nucleus and to the chromosome X territory determined for human lymphocytes

FALK Martin LUKÁŠOVÁ Emilie KOZUBEK Stanislav KOZUBEK Michal

Article in Periodical

Gene, year: 2002, volume: 292, edition: 1

2001

Exchange aberrations among 11 chromosomes of human lymphocytes induced by gamma-rays

GAŇOVÁ Alena LUKÁŠOVÁ Emilie KOZUBEK Stanislav KOZUBEK Michal GOVORUN Raisa KOUTNÁ Irena BÁRTOVÁ Eva SKALNÍKOVÁ Magdalena JIRSOVÁ Pavla PASEKOVÁ Renata KRASAVIN Evgenij

Article in Periodical

International Journal of Radiation Biology, year: 2001, volume: 77, edition: 4

2000

Topography of genetic loci in tissue samples: towards new diagnostic tool using interphase FISH and high-resolution image analysis techniques

KOUTNÁ Irena KOZUBEK Stanislav ŽALOUDÍK Jan KOZUBEK Michal LUKÁŠOVÁ Emilie MATULA Pavel BÁRTOVÁ Eva SKALNÍKOVÁ Magdalena CAFOURKOVÁ Alena JIRSOVÁ Pavla

Article in Periodical

Analytical Cellular Pathology, year: 2000, volume: 20, edition: 4