Project information
Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií
- Project Identification
- GAP304/10/1395
- Project Period
- 1/2010 - 12/2014
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- Monoclonal gammopathies; plasma cells; progenitors; phenotype; flow cytometry
Detailed study of heterogeneous subpopulations of myeloma cells and their precursors/progenitors in monoclonal gammopathy patients can lead to identification and characterisation of myeloma stem cells. Using polychromatic flow cytometry with sorting of cells, phenotype of myeloma stem cells can be detected and different subpopulation can be selected for clonality assessment. In vitro culturing then can prove self renewal capacity of these myeloma stem cells and their multidrug resistance as well. We suppose that using these approaches we are able to obtain new information in area of pathophysiology of myeloma cells and their behaviour, which can be potentially used for determination of predictive factors applicable in progression of monoclonal gammopaty of undetermined significance to multiple myeloma.
Publications
Total number of publications: 108
2012
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Evaluation of Immune Suppression in Multiple Myeloma Patients Treated with Lenalidomide Plus Prednisone and Lenalidomide Alone.
Year: 2012, type: Conference abstract
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Flow cytometry as a predictive tool for transpormation of MGUS into MM
Year: 2012, type: Conference abstract
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Functionally active myeloid-derived suppressor cells are increased after lenalidomide plus dexamethasone treatment in previously untreated multiple myeloma patients
Year: 2012, type: Conference abstract
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Functionally suppressive CD8 T regulatory cells are elevated in multiple myeloma patients: a detailed phenotypic, molecular and functonal characterization
Year: 2012, type: Conference abstract
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Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment
Public Library of Science one, year: 2012, volume: 7, edition: 11, DOI
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High levels of neural stem cell marker nestin are associated with 1q21 gain and predict whorse reposnse to conventional and novel therapy in multiple myeloma
Year: 2012, type: Conference abstract
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Identification of prognostic factors for malignant transformation in persons with monoclonal gammopathy of undetermined siificance observed in the Czech Republic
Year: 2012, type: Conference abstract
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Identifikace prognostických faktorů transformace v nádorové onemocnění u osob s MGUS sledovaných v České republice.
Year: 2012, type: Conference abstract
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Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma.
PLOS ONE, year: 2012, volume: 7, edition: 10, DOI
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Induction by lenalidomide and dexamethasone combination increases regulatory cells of patients with previously untreated multiple myeloma
Leukemia & Lymphoma, year: 2012, volume: 53, edition: 7, DOI