Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 251
2019
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Simultaneous study of mechanobiology and calcium dynamics on hESC-derived cardiomyocytes clusters
Journal of Molecular Recognition, rok: 2019, ročník: 32, vydání: 2, DOI
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Structural basis for the multitasking nature of the potato virus Y coat protein
Science advances, rok: 2019, ročník: 5, vydání: 7, DOI
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Structure-functional study of lectins: key players in a fight between host and pathogen
Rok: 2019, druh: Konferenční abstrakty
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Synthesis, structure, stability and phase diagrams of selected bimetallic silver- and nickel-based nanoparticles
CALPHAD-COMPUTER COUPLING OF PHASE DIAGRAMS AND THERMOCHEMISTRY, rok: 2019, ročník: 64, vydání: March, DOI
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The experimental and theoretical study of Bi-X (X = Sn, Ni) nanoalloys
Rok: 2019, druh: Konferenční abstrakty
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The first X-ray crystal structure of a mercury(II) complex with an SP(N)(3)-based ligand: Synthesis and crystal structure of SP(NC5H10)(3) and [Hg{SP(NC5H10)(3)}Cl-2](2)
Phosphorus, Sulfur, and Silicon and the related elements, rok: 2019, ročník: 194, vydání: 1-2, DOI
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The frequency and consequences of multipolar mitoses in undifferentiated embryonic stem cells
Journal of applied biomedicine, rok: 2019, ročník: 17, vydání: 4, DOI
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The theoretical and experimental study of the Sb-Sn nano-alloys
CALPHAD-COMPUTER COUPLING OF PHASE DIAGRAMS AND THERMOCHEMISTRY, rok: 2019, ročník: 64, vydání: 1, DOI
2018
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AB21, a protein of unknown function from Agaricus bisporus. A case study on utilizing experimental and bioinformatical approaches for functional assignment of unknown proteins
Rok: 2018, druh: Konferenční abstrakty
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Advanced and Rationalized Atomic Force Microscopy Analysis Unveils Specific Properties of Controlled Cell Mechanics
Frontiers in Physiology, rok: 2018, ročník: 9, vydání: AUG 17 2018, DOI