Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
-
Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 252
2019
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Human Telomere Repeat Binding Factor TRF1 Replaces TRF2 Bound to Shelterin Core Hub TIN2 when TPP1 Is Absent
Journal of Molecular Biology, rok: 2019, ročník: 431, vydání: 17, DOI
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Hypervalent Iodine Based Reversible Covalent Bond in Rotaxane Synthesis
Angewandte Chemie International Edition, rok: 2019, ročník: 58, vydání: 50, DOI
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Characterization of nanoparticles and proteins by AFM
Rok: 2019, druh: Uspořádání workshopu
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Laser-induced breakdown spectroscopy as a novel readout method for nanoparticle-based immunoassays
Microchimica Acta, rok: 2019, ročník: 186, vydání: 9, DOI
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Laser-Induced Breakdown Spectroscopy as a Novel Readout Method for Nanoparticle-Based Immunoassays
Rok: 2019, druh: Konferenční abstrakty
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Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts
ACS Catalysis, rok: 2019, ročník: 9, vydání: 6, DOI
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Magnetic nanoparticles for smart electrochemical immunoassays: a review on recent developments
Microchimica Acta, rok: 2019, ročník: 186, vydání: 5, DOI
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Maleic anhydride and acetylene plasma copolymer surfaces for SPR immunosensing
Analytical and Bioanalytical Chemistry, rok: 2019, ročník: 411, vydání: 29, DOI
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Morphology Control in AgCu Nanoalloy Synthesis by Molecular Cu(I) Precursors
Inorganic Chemistry, rok: 2019, ročník: 58, vydání: 22, DOI
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MSc. Students from Komensky University, Bratislava, SR
Rok: 2019, druh: Popularizační texty