Early Warning Biosensors for Detection of Chemical Warfare Agents.

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Authors	BIDMANOVÁ Šárka POHANKA Michal CABAL J. PROKOP Zbyněk DAMBORSKÝ Jiří
Year of publication	2010
Type	Article in Periodical
Magazine / Source	CHEMICKE LISTY
MU Faculty or unit	Faculty of Science
Citation
Web	http://loschmidt.chemi.muni.cz/peg/abstracts/chemlisty2010.html
Field	Biochemistry
Keywords	Chemical warfare agents;toxic compounds;biosensors
Description	Chemical warfare agents are toxic compounds showing negative effects on living organisms. This review focuses on detection of nerve and blister agents, which are two most important classes of chemical warfare agents. Main attention is paid to the construction and use of biosensors. Acetylcholinesterase, butyrylcholinesterase and phosphotriesterase are presented as convenient biorecognition components of biosensors for detection of nerve agents, while dehalogenases are useful for detection of mustard agents.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) Center of Biocatalysis and Biotransformation Specific ion effects for proteins in solutions and related biologically relevant systems Evolution of substrate specificity in enzymes acting on xenobiotic compounds