Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1209
2012
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Experimental Administration of the Probiotic Escherichia coli Strain Nissle 1917 Results in Decreased Diversity of E. coli Strains in Pigs
Current Microbiology, year: 2012, volume: 64, edition: 3, DOI
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Genetic diversity in Treponema pallidum: Implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws
Infection, Genetics and Evolution, year: 2012, volume: 12, edition: 2, DOI
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Genetický marker RGH1aE1 pro rezistenci k původci padlí travního u ječmene
Year: 2012
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Genetický marker RGH1aE2a pro rezistenci k původci padlí travního u ječmene
Year: 2012
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Genetický marker RGH1aE2I2 pro rezistenci k původci padlí travního u ječmene
Year: 2012
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Genetický marker RGH1aI1a pro rezistenci k původci padlí travního u ječmene
Year: 2012
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Human Escherichia coli strains of different geographical and time source: bacteriocin types and their gene sequences are population-specific
ENVIRONMENTAL MICROBIOLOGY REPORTS, year: 2012, volume: 4, edition: 4, DOI
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Characteristics and distribution of plasmids in a clonally diverse set of methicillin-resistant Staphylococcus aureus strains
Archives of Microbiology, year: 2012, volume: 194, edition: 7, DOI
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Identification and determination of relatedness of lactobacilli using different DNA amplification methods
Chemical Papers, year: 2012, volume: 66, edition: 9, DOI
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Identification of cytokinin receptors of Brassica napus
Year: 2012, type: Conference abstract