Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1209
2012
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Classification of Pseudomonas spp. isolated from Antarctic samples
Year: 2012, type: Appeared in Conference without Proceedings
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c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis
Molecular Cancer, year: 2012, volume: 11, edition: MARCH, DOI
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Complete genome sequence of Treponema pallidum strain DAL-1
Standards in Genomic Sciences, year: 2012, volume: 7, edition: 1, DOI
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Complex karyotype and translocation t(4;14) define patients with high-risk newly diagnosed multiple myeloma: results of CMG2002 trial
Leukemia & Lymphoma, year: 2012, volume: 53, edition: 5, DOI
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Determination of Lead in Submicroliter Samples of Whole Blood using Laser Diode Thermal Vaporization
Year: 2012, type: Conference abstract
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Developmental maintenance of general epigenetic pattern of the Arabidopsis thaliana TERT (telomerase protein subunit) chromatin
Year: 2012, type: Appeared in Conference without Proceedings
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Different immune response of pigs to Mycobacterium avium subsp. avium and Mycobacterium avium subsp. hominissuis infection
Veterinary Microbiology, year: 2012, volume: 159, edition: 3-4, DOI
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Diode laser thermal vaporization inductively coupled plasma mass spectrometry
Analytical Chemistry, year: 2012, volume: 84, edition: 5, DOI
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Dynamic Evolution of Telomeric Sequences in the Green Algal Order Chlamydomonadales
GENOME BIOLOGY AND EVOLUTION, year: 2012, volume: 4, edition: 3, DOI
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Efficient transfer of antibiotic resistance plasmids by transduction within methicillin-resistant Staphylococcus aureus USA300 clone
FEMS Microbiology Letters, year: 2012, volume: 332, edition: 2, DOI