Project information
Application of computer image analysis in optical microscopy
- Project Identification
- MSM 143300002
- Project Period
- 1/1999 - 12/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Informatics
- Keywords
- image analysis; image processing; segmentation; preprocessing; deconvolution; 3D analysis; 3D reconstruction; mathematical morphology; parallel computing; parallel algorithms; optical microscopy; confocal microscopy; automation; automated microscopy
Aim: The aim of the project is the research in the field of computer analysis of microscopic images, in the field of automation of the acquisition process and on-line image analysis and application of gained knowledge in praxis. The proposal assumes both continuation of running research of cell nucleus structure with clinical applications in diagnostics and prevention of leukemias and other cancer diseases as well as extension of the research into other application areas of computer analysis of microscopic images, biomedical as well as industrial. Content: Especially the algorithms of image preprocessing and segmentation will be studied with emphasis on deconvolution of 3D images, mathematical morphology operations and 3D image reconstruction from a series of 2D image slices. An intensive research will be led also in the area of parallel image analysis algorithms and parallelization of selected algorithms on multi-processor workstations using the equipment of Supercomputing centre MU.
Results
The aim of the project is the research in the field of computer analysis of microscopic images, in the field of automation of the acquisition process and on-line image analysis and application of gained knowledge in praxis.
Publications
Total number of publications: 88
1999
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Chromatin structure and its cell cycle kinetics in intact and irradiated cell nuclei
Fundamentals for the assesment of risks from environmental radiation, year: 1999
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Chromosomes participating in translocations typical of malignant hemoblastoses are also involved in exchange aberrations induced by fast neutrons
Radiation Research, year: 1999, volume: 151, edition: 4
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The position of centromeres in interphase nuclei of human leukemic cells during myeloid differentiation and after gamma-irradiation
Fluorescence microscopy and fluorescent probes, year: 1999
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The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9,22) translocations and in the pathogenesis of t(9,22) leukemias
Chromosoma, year: 1999, volume: 108, edition: 7
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Topography of some genes and chromosomes in interphase nuclei of human cells
Fluorescence microscopy and fluorescent probes, year: 1999
1994
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A bisection method to find all solutions of system of nonlinear equations.
Domain Decomposition Methods in Scientific and Engineering Computing, year: 1994, number of pages: 1 s.
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Complexes between osmium tetraoxide bispyridine and DNA: a molecular mechanics study
J. Biomol. Struct. Dynamics 12, year: 1994, volume: 1994, edition: 12
1993
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Decomposition of arithmetical NP-hard problems.
Inter. J. Computer Math. 48, year: 1993, volume: 1993, edition: 48